Enrico de Lazaro reports for Science News:
South American Medicinal Plant Compound Shows Anti-Cancer Stem Cell Activity
Damsin, a natural compound isolated from the South American medicinal plant Ambrosia arborescens, has been found to inhibit the growth of cancer stem cells, according to new research.
“Cancer stem cells can be considered as the most dangerous type of cancer cells, as they appear to have an inherent resistance to the chemotherapeutic drugs used today,” said Lund University Professor Stina Oredsson, corresponding author of the study, published in the journal PLoS ONE.
“Our results can contribute to the development of new drugs against cancer stem cells but, unfortunately, it takes a long time to get from basic research to usable drugs.”
Professor Oredsson and her colleagues from Lund University in Sweden and the University Major of San Andrés in Bolivia studied the effect of damsin and its synthetic derivative called ambrosin on cancer stem cells in three different breast cancer cell lines.
“Both damsin and ambrosin inhibit the growth and spread of cancer stem cells in breast cancer cell lines,” Professor Oredsson said.
“This is the first time that it has been successfully proven by research.”
Even at low concentrations, the two substances inhibit the division and mobility of the cancer cells. This means that the tumor becomes smaller as cell proliferation decreases.
“In the present study, we show that the actual number of cancer stem cells decreases,” Professor Oredsson said.
“This is basic research and the results are based on lab experiments involving cell cultures.”
“However, the results are a breakthrough in cancer research as it may be the first step towards effective treatment of cancer stem cells, i.e. the cells believed to cause metastases.”
W.S. Sotillo et al. 2017. Anti-cancer stem cell activity of a sesquiterpene lactone isolated from Ambrosia arborescens and of a synthetic derivative. PLoS ONE 12 (9): e0184304; doi: 10.1371/journal.pone.0184304
Bolivian Thoughts opinion: This is the nest possible example why we MUST protect our biodiversity!
Bolivia has been blessed as it is considered a mega diverse country. As such, we need to protect our wildlife at all costs! Unfortunately, we are currently under the domain of a coca grower caudillo who cares less for our biodiversity, let alone indigenous communities. Over the last 11 years, he managed to make us lose the first place in the world with the greatest natural sustainable forest in the world!
This petty individual now attempts to cut in half the TIPNIS with a useless road, that will only benefit illegal settlers who will destroy the forest and plant coca, which will later on will become cocaine …
The world MUST help Bolivia stop this egomaniac, we only ask he finishes his third illegitimate presidency and go home, this ochlocrat intends to remain president, breaking the Constitution he himself imposed by force …